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Authors

Gudisa Bereda

Abstract

Elevated blood sugar levels, which are either brought on by inadequate insulin synthesis by the pancreas or by incorrect insulin usage by the body, characterize diabetes mellitus, a chronic metabolic disease. Diabetes mellitus can cause renal failure, and those with the condition are at least 10 times more likely to have to amputate a foot due to diabetes than those without it. High blood sugar levels are thought to contribute to kidney and heart problems. A rapid rate of beta cell malfunction and sequences resulting from an absolute lack of insulin hormone secretion may be used to describe type 1 diabetes mellitus. Type 1 diabetes mellitus often manifests itself in young patients, although it may also affect adults. Diabetic neuropathy, one of the most severe microvascular complications of diabetes mellitus, is characterized by a metabolic-vascular disorder that compromises the structure and function of peripheral somatic or autonomic nerves without inducing inflammation. Dehydration brought on by osmotic diuresis, which impacts hyperviscosity and a hypercoagulable condition, and elevated blood glucose levels are typical symptoms of a hyperosmolar hyperglycemic state. People with type 1 diabetes are 12 times more likely than those with type 2 diabetes to develop diabetic nephropathy.

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REVIEW