Correlation of carotid intima media thickness with SGOT in diabetic patients–An analytical cross-sectional study in a tertiary care hospital

Abstract

Background: Uncontrolled diabetes mellitus predisposes to atherosclerotic cardiovascular diseases like coronary artery disease, Stroke leading to illness, complications, and death. Carotid intima media thickness (CIMT), performed by radiologists being simple and noninvasive, has been regarded as a tool to diagnose early atherosclerosis. Aspartate aminotransferase (AST) is a cardiac biomarker whose level will be elevated in myocardial injury and inflammation. This study was conducted to find correlation of SGOT with CIMT in diabetes patients.

Methods: 29 patients with type 2 diabetes mellitus were selected for this hospital-based analytical cross-sectional study. SGOT and CIMT were measured. The correlation between SGOT and CIMT was analyzed using Pearson correlation analysis.

 Results: Of the 29 patients enrolled 34.5 % were female and 65.5 % were male. A statistically significant correlation was found between HbA1C, FBS with CIMT (p <0.001). The mean age was 66.32 ± 10.981. 55% of the patients had CIMT more than 0.9 mm. We found a statistically significant correlation between SGOT and CIMT r = 0.415 with a p-value of 0.025.

Conclusion: SGOT is having a positive correlation with CIMT in diabetic patients. Hence SGOT can be utilized as a marker to prognosticate early atherosclerotic cardiovascular events like stroke and ischemic heart disease in diabetic individuals.