Implanting decellularized plant tissue containing CAR-T cells at debulked tumor sites

Abstract

Surgical treatment of cancer includes the removal of the entire tumor. Sometimes, surgery removes some, but not all, of cancer tumors regarding the safety of the organ. This is called debulking. The debulked site contains some cancer cells. CAR-T cell therapy is a cancer immunotherapy that uses T cells of patients to fight against cancer cells. T cells collected from patients’ blood are genetically modified using chimeric antigen receptor (CAR) gene. The modified T cells are grown in a culture medium. Decellularization is the process of sterilizing a preexisting natural organ to the extent that only the extracellular matrix scaffold base remains. The CAR-T cells injected decellularized plant tissues are used as an effective treatment against cancer cells present at debulked tumor sites