Early prediction of brain tumors postoperative progression of using the peripheral blood cells aggregation level indicators by surface Plasmon resonance method

Abstract

The completeness of brain tumors removal, on which the continued growth depends, was determined using indicators of the peripheral blood cell aggregation level of using a SPR analyzer before and on the 7th day after surgery. An increase in the sensitivity of the method was achieved by adding a 0.25% solution of verapamil hydrochloride (Farmak) diluted 10,000 times to the blood under in vitro conditions. A decrease in SPR values on the 7th day after surgery compared to preoperative data may indicate total removal of the patient’s tumor. If SPR indicators on the 7th day after surgical removal are increased compared to preoperative values, this indicates the presence of a tumor and tumorassociated inflammation and, therefore, subtotal removal of the tumor and the likelihood of relapse due to tumor progression.