Exposure to aluminum nanoparticles: Cognitive impairments and Alzheimer-like impact

Abstract

Recent findings implicate aluminum (Al) as a contaminant in the cause of progressive damage to the structure and function of neurons, which can cause neuronal cell death and may lead to cognitive impairment, learning, and memory impairment in older adults, resembling the damage of Alzheimer’s disease (AD). However, there is still no solid evidence to prove it. The idea of a role for Al in the origin, development, and severity of AD has existed for many years. Although the role of Al in AD is becoming increasingly clear, the underlying toxic mechanism remains unclear. This small review describes the morphological features and effects of Al exposure on neuronal cell death and cognitive challenges following exposure to Al nanoparticles.